State Security of Uzbekistan: Challenges and Prospects amid Global Transformations. State security in Uzbekistan is analyzed as a cornerstone of national sovereignty and development. In an era of globalization, the country encounters a spectrum of threats ranging from international terrorism and transnational crime to cyber vulnerabilities and geopolitical instability. This article identifies the key challenges to Uzbekistan’s state security, examines their causes and implications, and suggests avenues for strengthening national security mechanisms. Emphasis is placed on the role of civil society, the evolution of the legal framework, and the need for cooperative relations with international partners. Drawing on historical context and current trends, the paper articulates a strategic outlook for developing a resilient and adaptive security system. It advocates a comprehensive approach that integrates legal, social, and technological measures while upholding human rights and promoting sustainable development.