This article analyzes the transformation of Uzbekistan–Türkiye relations during the presidency of Shavkat Mirziyoyev. It examines the development of political, economic, cultural, and strategic cooperation between the two countries, as well as Uzbekistan’s growing role within the Organization of Turkic States. Special attention is given to Mirziyoyev’s initiatives on regional integration, transport and logistics corridors, green economy, and food security. The study highlights how strengthened bilateral ties and multilateral engagement contribute to regional stability and shared prosperity in the Turkic world.