This article analyzes the formation and development of knowledge from the perspective of semiotic systematization. Knowledge is interpreted as a process through which information about the external world is transformed into a symbolic-cognitive construct by means of sensation, perception, experience, logical generalization, and social agreement. The article examines the emergence of signs, symbols, sounds, words, texts, and concepts, as well as the mechanisms by which they are transformed into knowledge, on the basis of naturalistic, conventional, anthropological, and cognitive approaches. It also distinguishes genetic, artificial, and social forms of knowledge and explains their role in human thought, experience, cultural relations, and the system of formal education.